Police are asking drivers to try to avoid the A27 at Fishbourne following a serious collision between at lorry and a car, at 1.05pm today (Thursday 5 March).
The lorry jack-knifed blocking the road at the Fishbourne roundabout eastbound.
The woman driver of the car suffered a serious injury and has been flown by the air ambulance to Southampton General Hospital. The lorry driver was not hurt.
The road is closed eastbound and is not likely to re-open for at least another two hours. It is open westbound but is heavily congested. Drivers are asked to avoid the area if possible.