No trains between Hastings, Battle and Tunbridge Wells will be running this Saturday (March 23).
Southeastern said the route is being closed due to engineering works.
As a result, buses will replace trains between Tunbridge Wells and Hastings.
Southeastern said because of limited road access, a minibus service will also run between Battle and Crowhurst.
The line was recently closed for several days due to landslips at Wadhurst.
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